How does SAJAZIR (icatibant) work?
Hereditary angioedema (HAE) is usually caused by your body not producing enough of, or not properly producing, a blood protein called C1 inhibitor.1–5 This leads to your body producing too much of another protein called bradykinin, which causes an HAE attack.1–5
When you are having an HAE attack, fluid in your blood vessels leaks out into the surrounding area, causing painful and sometimes disfiguring swelling—most often in your face, feet, hands, stomach, genitals, and even your throat, which can be dangerous.1–6 SAJAZIR works by preventing bradykinin from attaching to receptors found on the lining of blood vessels, which limits their activity and reduces the symptoms of the HAE attack.6
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References
- Maurer M, et al. Allergy. 2018;73(8):1575–1596.
- Zuraw BL, et al. J Allergy Clin Immunol Pract. 2013;1(5):458–467.
- El-Shanawany T. Hereditary Angioedema. British Society for Immunology. https://www.immunology.org/public-information/bitesized-immunology/immune-dysfunction/hereditary-angioedema (accessed October 2021).
- Ghazi A, Grant JA. Biologics. 2013;7:103–113.
- Lumry W, et al. Journal of Infusion Nursing 2020;43(3):134–145.
- SAJAZIR™ (icatibant) Injection. Prescribing Information. Cycle Pharmaceuticals Limited.